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Proton-pump inhibitors (PPIs) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production. They are the most potent inhibitors of acid secretion available. This group of drugs followed and largely superseded another group of medications with similar effects, but a different mode of action, called H2-receptor antagonists. PPIs are among the most widely sold drugs in the world, and the first one, omeprazole, is on the World Health Organization's List of Essential Medicines. ==Medical uses== These drugs are used in the treatment of many conditions, such as: * Dyspepsia〔 〕 * Peptic ulcer disease including after endoscopic treatment for bleeding * As part of Helicobacter pylori eradication therapy〔 〕 * Gastroesophageal reflux disease (GERD or GORD) including symptomatic endoscopy-negative reflux disease〔 〕 and ::associated laryngopharyngeal reflux causing laryngitis〔 〕 and chronic cough〔 〕 * Barrett's esophagus〔 〕 * Eosinophilic esophagitis〔 〕 * Stress gastritis and ulcer prevention in critical care〔 〕 * Gastrinomas and other conditions that cause hypersecretion of acid including Zollinger–Ellison syndrome (often 2–3x the regular dose is required) Specialty professional organizations recommend that people take the lowest effective PPI dose to achieve the desired therapeutic result when used to treat gastroesophageal reflux disease long-term.〔(【引用サイトリンク】publisher=American Gastroenterological Association )〕 In the United States, the Food and Drug Administration has advised that no more than three 14-day treatment courses should be used in one year.〔 Despite their extensive use, the quality of the evidence supporting their use in some of these conditions is variable. The effectiveness of PPIs has not been demonstrated for every case. For example, although they reduce the incidence of esophageal adenocarcinoma in Barrett's oesophagus,〔 they do not change the length affected. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Proton-pump inhibitor」の詳細全文を読む スポンサード リンク
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